About the OPTimize NOW Study

The OPTimize NOW study will help us learn more about how to best care for babies with Neonatal Opioid Withdrawal Syndrome, also called NOWS. Babies with NOWS often have tremors, a hard time sleeping, excessive crying, and trouble feeding. Some babies that have NOWS need medicine. Doctors have two ways of providing medicine that are widely used today:

  1. Scheduled opioid taper approach. The baby gets medicine at regular times. As symptoms get better, the amount of medicine a baby gets decreases until the baby no longer needs medicine. This is called a medicine taper.

  2. Symptom-based approach. The baby will only get medicine when they show signs of NOWS, instead of at regular times. If a baby is showing no signs of NOWS, no medicine will be given.

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There are 27 Clinical Sites participating in the OPTimize NOW study.